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Phentermine (Adipex-P) is an amphetamine like stimulant that is commonly used as an appetite suppressant. It is used to aid in weight loss in obese people, especially when there are associated health risks associated with being overweight. Phentermine is used in short-term weight loss programs, combined with diet, exercise, and lifestyle changes. Phentermine is most commonly used for weight loss, but it can also be used in combination with the drug Topiramate to help with certain eating disorders, such as binge eating disorder (BED).

Phentermine (Adipex-P)

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Phentermine (Adipex-P) works by stimulating the central nervous system, which increases your heart rate and blood pressure and reduces appetite. Phentermine mainly affects the appetite-regulating hypothalamic region of the brain and causes the release of neurotransmitters that create a feeling of satiety and reduce hunger.

How Does Phentermine (Adipex-P) Work?

Phentermine belongs to a class of drugs called anorectics, also known as appetite suppressants. Taking Phentermine helps suppress your appetite, thereby limiting the number of calories you consume. Over time, this can lead to weight loss. Although the exact way in which Phentermine reduces appetite remains unclear, it is believed that the drug works by increasing the levels of neurotransmitters in your brain.

Neurotransmitters-the chemicals noradrenaline, serotonin, and dopamine-are your body's chemical messengers. When your levels of these three chemicals increase, your feelings of hunger decrease. However, within a few weeks, you may develop a tolerance to the appetite-suppressing effects of Phentermine. If this happens, talk to the health care provider who prescribed it.


  • Dependence and Tolerance: Due to the risk of dependence and tolerance, Phentermine is intended for short-term use only.
  • Cardiovascular Disease: Patients with a history of cardiovascular disease should use Phentermine with caution.
  • Interactions with Other Drugs: Phentermine may interact with a number of other medications, so consultation with a physician is necessary before use.

Side Effects

Phentermine itself is intended for short-term use only, as there are few long-term studies on its safety. One study noted that people experienced no significant side effects when taking Phentermine for up to 24 months. However, the FDA has approved Phentermine in combination with Topiramate for long-term use because the doses of the two ingredients are lower than the maximum doses of the individual drugs.

The most commonly reported side effects of Phentermine and combined Phentermine and Topiramate are:

  • Dry mouth
  • Sleep problems
  • Dizziness
  • Heart palpitations
  • Hyperemia of the skin
  • Fatigue
  • Constipation
  • Irritability
  • Nausea
  • Vomiting

Although rare, some severe side effects are possible, such as increased blood pressure, suicidal ideation, metabolic acidosis, increased creatinine levels, fetal harm, vision problems, cognitive impairment, and hypokalemia.

Also, be sure to consult a health care provider before trying Phentermine if you are taking certain medications, such as monoamine oxidase inhibitors (MAOIs). While Phentermine can be a helpful weight loss tool, it is not recommended as a first-line treatment. Instead, it is better to prioritize healthy lifestyle changes for long-term success.

Phentermine and Topiramate

A combination of Phentermine and Topiramate - marketed under the trade name Qsymia - is a medication used for weight loss. This medication is available in four doses, with strengths ranging from 3.75-15 mg of Phentermine and 23-92 mg of Topiramate. It is offered in prolonged-release capsules that should be taken in the morning.

After you take the lowest dose for 14 days, your doctor may decide to switch you to a higher dose. According to the FDA, you should stop using the medicine if you do not lose 3% of your body weight after 12 weeks of taking the highest daily dose.


Phentermine (Adipex-P) is an effective appetite suppressant for short-term use in a weight loss program. However, its use requires careful medical supervision and adherence to all dosage and duration of treatment recommendations. It is important to consider potential risks and side effects, especially in the presence of cardiovascular disease or when taken